Anthony Scianna’s Storybook Ending

























a11e5  etc openerfairytale45  02  inline202 Anthony Sciannas Storybook EndingFrancesco Nazardo for Bloomberg BusinessweekA typical Friday night at FairyTail Lounge


To enter the FairyTail Lounge, a one-year-old New York nightclub opened by three former commodities traders, guests pass through a sparkle-splattered door into a small room so shimmery it looks like it was painted by Tinker Bell. Above the bar, two male garden gnomes perch on an overhead shelf, frozen in ceramic ecstasy, one’s face pressed against the other’s glazed butt.





















a11e5  etc openerfairytale45  01  inline202 Anthony Sciannas Storybook EndingFrancesco Nazardo for Bloomberg Businessweek


On a dank Saturday night, the only things more dazzling than the bar itself are Roxy Brooks and Lauren Ordair, two drag queens bedecked with enough costume jewelry to sink a pirate ship. “It’s just terrible what happened to those people,” says Ordair, referring to the nearly 1,000 commodities traders who’ve lost their jobs over the last two years. “But it’s happening everywhere. Drag wasn’t my first choice, you know. I studied to be an opera singer. Turns out it’s a small field.” Now the tenor soprano belts out show tunes at FairyTail on Mondays, where one of those laid-off traders, her boss, has just arrived.


“Anthony!” the drag queen suddenly chimes, Cheers-style, as she waves to the bar’s proprietor, Anthony Scianna, a 50-year-old wearing a zip-up cardigan. If Scianna’s job hadn’t been made obsolete, the FairyTail Lounge might be nothing more than fantasy.


Once upon a time, not so very long ago, a pauper could become a prince if he knew the right person. A reliable guy like Scianna, from a working-class family on Staten Island, didn’t need an MBA, or even a college education, to make good money fast as a floor trader. Moving soft commodities such as cotton, coffee, cocoa, sugar, and frozen concentrated orange juice was an old-school apprenticeship: There was no employment office, no interview, just guys who knew guys. All a pauper needed was a loud voice, a sky-high tolerance for stress, and a friend to vouch for him. Scianna got invited to the ball and worked the business for 20 years, from 1990 until last fall, when it became clear that Cinderella’s clock was going to strike midnight any minute.


As recently as early 2011, 90 percent of soft-commodity options were traded on the floor in an open-outcry tradition—a loud, brash system of hand signals, shouts, and frenzied person-to-person deal- making—going back roughly 142 years. But as electronic trading exploded, that percentage has flipped: About 1,000 traders used to work the floor; that number was down to 100 by Oct. 19, when IntercontinentalExchange (ICE) (ICE) closed its floor altogether and completed the transition to computerized trading. It’s an historic shift in the way business gets done and a clear-cut case of humans being replaced by machines. As the system grows more efficient, these jobs are disappearing, and so goes a tribe of Wall Street.


“I had a beautiful life. It was a beautiful experience,” Scianna says in his New York accent, the day after those layoffs left many of his old friends unemployed. “When I would walk into work, it felt like going home. We really were one big beautiful family.” A beautiful family from whom he hid that he was gay for 15 years, but more on that later.


Leaning against a pile of purple velvet pillows, Scianna says he liked the money, the camaraderie, the Cipriani parties, and the great hours: After coffee trading closed at 1:30 p.m., the rest of his day was free. And he thrived on the stress. “It never made me nervous, it made me excited,” he says. “One time, I witnessed a wonderful man, the father of a dear friend, pass away in the ring, trading copper. They just pulled him out and it kept going. The market never stopped.”


Scianna spent two decades trading futures but never thought much about his own. “Then we watched the business go from what it was to nothing. Suddenly the guy next to you was gone,” he says. “In 2010 I was 48, and I said to myself, ‘Who’s going to hire me? I don’t have any other skills.’ So I needed an idea.”


The find-yourself chick flick Eat Pray Love is playing on the TV above the bar, muted, as Scianna explains that he, like Julia Roberts, began his own second act after a bad breakup. A friend told him he had to get back out there, so Scianna hit Manhattan’s gay club scene. “I noticed every single gay bar was always packed,” he says. “All night long.”


This was a growth business with a future: Bartenders, go-go dancers, and drag queens would not be replaced by machines, at least not any time soon. So Anthony pitched his idea for the FairyTail Lounge to two fellow ICE traders, Joe Carman and Dave Dwyer, who looked over the numbers and signed on as investors in the fall of 2010. Scianna immediately quit his job trading coffee for Chicago-based SMW Trading.


When SMW closed down his old division three months later, Scianna was already at work renovating a space at 48th Street and 10th Avenue, with mixed results. Veteran gay club party promoter Joseph Israel, a flashy Puck on the nightlife circuit, says Scianna’s original bar design was too, well, “ugh.” So he persuaded Scianna to allow him to queer up the place. “The bar was plain, plain, plain,” says Israel with a shiver. “The decoration didn’t even have a fairy tale theme!” So Israel conceived a wonderland of unicorns, satyrs, glitter, and a black-light poster that stars Walt Disney’s (DIS) Prince Charming as a foot fetishist and Snow White being pleased by all seven dwarves.


In a way, it’s not surprising that Scianna’s original idea for the bar was more subdued. He’d spent most of his adult life on conservative Wall Street, where almost everyone was straight—or acted like it. No matter how much he loved his job, he spent about the first 15 years of his career afraid that the more powerful old-timers would find out he was gay and fire him.


“You couldn’t take that chance,” he says, as a slender DJ with a flat-top begins spinning house music in a tiny booth. “You have to realize, Wall Street was a private club for very wealthy people. So I never led anybody to believe that I was gay. In those early days, I didn’t want anyone to have a reason to get rid of me.” He finally came out to co-workers after Sept. 11. “I said, ‘This is who I am. I’m not going to change or come in with a dress on.’ And a lot of the old-timers were gone by then, so it was OK.”


Scianna’s still working in a loud, noisy room filled almost entirely with competitive men who aggressively swap digits. Only instead of bulls and bears, it’s centaurs and unicorns. And instead of waking up at 5 a.m. to make the commute from Staten Island to Wall Street, he’s getting home from the bar around 5:30 a.m., dusted with sparkles. He has new responsibilities as a bar owner—employees, vendors, the glitter supply—but it’s working. When his friend Joanne Cassidy lost her job as a clerk in the ICE layoffs after 20 years on the floor, Scianna was able to give her work as a coat-check girl to tide her over. “There’s a family feeling to the place,” says Cassidy. “It’s like Cheers.”


Scianna says he’s definitely happier, but he sometimes misses the respect, the macho glitz, the big bonuses. “Trading, you could be an a– –hole, you could be cocky,” he says. “You didn’t make money one day? F– – – you, you’d make it tomorrow. Here, I have to take care of so many people.”


“I almost wish I didn’t taste it,” he says of Wall Street. “It’s like the pauper who tastes what it’s like to be rich—the instant gratification of knowing exactly how much money you made every day at 2:30. I’m all right now, but there are employees to pay, vendors, staffing issues. I don’t know how much I’ve made till I pay all the bills.” Scianna is figuring it all out as he goes.


It’s getting close to midnight—almost time for free shots!—and as the go-go boy writhes, the dance floor fills up with handsome young men and Julia Roberts shoves pasta into her face on the bar television. Scianna smiles. Maybe he hasn’t found his happily ever after, but, he says, “it’s a totally whole new life. This is my second act.”


a11e5  etc openerside45 405 Anthony Sciannas Storybook Ending


Businessweek.com — Top News



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Syrian rebels kill 28 soldiers, several executed

























BEIRUT (Reuters) – Anti-government rebels killed 28 soldiers on Thursday in attacks on three army checkpoints around Saraqeb, a town on Syria’s main north-south highway, a monitoring group said.


Some of the dead were shot after they had surrendered, according to video footage. Rebels berated them, calling them “Assad’s Dogs”, before firing round after round into their bodies as they lay on the ground.





















The highway linking the capital Damascus to the contested city of Aleppo, Syria’s commercial center, has been the scene of heavy fighting since rebels cut the road last month. Saraqeb lies about 40 km (25 miles) south of Aleppo


In other developments, China put forward a new initiative to resolve the 19-month-old conflict, including a phased, region-by-region ceasefire and the setting up of a transitional governing body.


A Chinese Foreign Ministry spokesman said Beijing had made the proposal to international peace envoy Lakhdar Brahimi – whose own call for a truce over the Muslim holiday of Eid was largely ignored by both sides.


The United States meanwhile has called for an overhaul of Syria’s opposition leadership, signaling a break with the largely foreign-based Syrian National Council to bring in more credible figures.


A meeting in Qatar next week of foreign powers backing the rebels will be an opportunity to broaden the coalition against President Bashar al-Assad, U.S. Secretary of State Hillary Clinton said in Zagreb on Wednesday.


The United States and its allies have struggled for months to craft a credible opposition coalition, while Assad has counted on the support of Russia, Iran and, to a lesser extent, China. International efforts to end the violence have all foundered.


More than 32,000 people have been killed since protests against Assad, an Alawite who succeeded his late father Hafez in ruling the mostly Sunni Muslim country, first broke out on city streets. The revolt has since degenerated into full-scale civil war, with the government forces relying heavily on artillery and air strikes to thwart the rebels.


CHECKPOINT ATTACKS


The army has lost swathes of land in Idlib and Aleppo provinces but is fighting to control towns along supply routes to Aleppo city, where its forces are fighting in many districts.


The head of the pro-opposition Syrian Observatory for Human Rights, Rami Abdelrahman, said two of the attacked checkpoints at Saraqeb were on the Damascus-Aleppo highway. The third was near a road linking Aleppo with Latakia, a port city still mostly controlled Assad’s forces.


“The rebels will not stay at the checkpoints for long as Syrian warplanes normally bomb positions after rebels move in,” Abdelrahman said.


Five rebels died in the fighting and at least 20 soldiers were killed at the third site, including those shot after surrendering, he said.


The video footage showed a group of petrified men, some bleeding, lying on the ground as rebels walked around, kicking and stamping on their captives.


One of the captured men says: “I swear I didn’t shoot anyone” to which a rebel responds: “Shut up you animal … Gather them for me.” Then the men are shot dead.


Reuters could not independently verify the footage.


The Observatory said the al Qaeda-inspired Jabhat al-Nusra rebel group was responsible for the executions.


Islamist rebel units are growing in prominence in the war – a cause for concern for international powers as they weigh up what kind of support to give the opposition.


U.S. President Barack Obama’s administration has said it is not providing arms to internal opponents of Assad and is limiting its aid to non-lethal humanitarian assistance. It concedes, however, that some of its allies are providing lethal assistance.


Russia and China have blocked three U.N. Security Council resolutions aimed at increasing pressure on the Assad government, leading the United States and its allies to say they could move beyond U.N. structures for their next steps.


China has been strongly criticized by some Arab countries for failing to take a stronger stance on the conflict. Beijing has urged the Assad government to talk to the opposition and take steps to meet demands for political change.


“More and more countries have come to realize that a military option offers no way out, and a political settlement has become an increasingly shared aspiration,” Chinese Foreign Ministry spokesman Hong Lei said in Beijing.


He said China’s new proposal was aimed at building international consensus and supporting peace envoy Brahimi’s mediation efforts.


(Additional reporting by Ayat Basma, Laila Bassam and Dominic Evans in Beirut and Terril Yue Jones in Beijing; Writing by Oliver Holmes; Editing by Angus MacSwan)


World News Headlines – Yahoo! News



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Researchers Predict Twitter Trends With 95% Accuracy [STUDY]

























Researchers at MIT say they’ve created an algorithm for Twitter that predicts trending topics better than the site’s existing equation.


[More from Mashable: Explore Obama and Romney’s Most Engaging Tweets With This Map]





















Associate Professor Devavrat Shah and student Stanislav Nikolov say their new algorithm predicts trending topics with 95% accuracy an average of 90 minutes faster than Twitter — sometimes, as early as five hours before.


[More from Mashable: Scared Twitless: Our Favorite 140-Character Halloween Stories]


The algorithm combs through a large sample of tweets — some that trended well, and some that didn’t — and compares the data to new information to see if there are any patterns. If new tweets look like older tweets that have trended, then there’s a chance a new trend is being formed. Simple.


The equation could be applied to anything that changes over time, the researchers say, like the stock market, movie ticket prices or the duration of a bus ride. For Twitter, the data could prove beneficial to advertisers looking to market a certain topic or trend.


Check out the video above to learn more. What other trends — on Twitter or otherwise — would you like to see better predicted? Tell us what you think.


Image courtesy of Flickr, shawncampbell.


This story originally published on Mashable here.


Social Media News Headlines – Yahoo! News



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The Sandy 15? Superstorm comfort-eating on menu

























Jamie Sanders went to the grocery store in the aftermath of superstorm Sandy with good intentions. Cucumbers and apples were on her list.


But her local supermarket hadn’t gotten any new supplies — and with the prospect of working in her Upper East Side apartment for several days ahead, she joined the hordes of East Coast residents holed up in their homes who found comfort in the bottom of a crinkly bag, a brightly colored box or a perfect pint-sized cardboard container.





















“There was some canned food left and some Oreos,” the copywriter and beauty blogger said. “I do like Oreos, but these were an impulse buy. I saw they were Winter Oreos with red cream and a snowman on top and I had to try them.”


Chips and salsa also went into the cart, although she would have preferred Doritos if any were left, and she sheepishly admitted to making a meal of some boxed macaroni and cheese, too.


Facebook and Twitter were full of similar mini-confessions of calories consumed while people were either left in the dark and trying to eat up what was deep in their freezer before it thawed, or making due with the shelf-stable, packaged foods that were in the grocery store after the meat and produce were gone. Others turned to baking as a rainy day family activity.


Add to that the Halloween candy that many people bought for trick-or-treaters and it really was “the perfect storm,” said New York-based registered dietician Keri Glassman.


Glassman, author of the upcoming book “The New You and Improved Diet,” said stress and boredom make it hard to fight off temptation. Her advice: don’t eat it all in one sitting. “If you have that candy in the house, make it one treat a day for the next few days.”


Oreos were also on the menu at Jill Nawrocki’s home in Brooklyn, although hers are of the Double Stuf variety.


She is preparing to run in Sunday’s New York Marathon and had been expecting to be eating protein and leafy greens this week, but it wasn’t meant to be. “I usually do my grocery shopping on Sunday, which didn’t happen this week, so my cupboards were pretty bare,” she said via email.


She had stocked up last year on “pretty gross” non-perishable foods during Hurricane Irene and didn’t want to make that same mistake.


Even fitness trainer Simone de la Rue gave into a burger, french fries and margarita on Tuesday — for lunch, no less.


“I’m going stir crazy myself. I have a little cabin fever,” de la Rue said. “I never do this, but it helped me pass the time.”


Nancy Yates, a retired United Nations development officer who lives in desolate lower Manhattan, where thousands of people are still living without power, went shopping with neighbor Norma Fontane for comfort food at a bodega lit by flashlight and candlelight.


They picked up canned chicken noodle soup and crackers, chocolate bars, chips and cookies — “to help the depression,” Fontane joked.


Extra time prompted Matthew Bautista, a publicist in Harlem, to go really far in the other direction: Instead of junk food, he has spent the last four days concocting gourmet meals. “I’ve been homebound, so I used my Dutch oven for the first time,” he said.


His lights stayed on, so one night it was spare ribs braised in red wine, another it was butternut squash soup, and there’s still a pork loin to cook. He has invited neighbors and friends who are without power or affected by flooding to join him.


But now he knows that his local gym is open, so he is planning on squeezing that in between meals.


Still without power at her apartment or West Chelsea studio on Wednesday, de la Rue was making up for her indulgences with a few extra workout videos streamed on her iPad.


For fellow storm binge-eaters, she suggests candlelight yoga or any sort of household cleaning that requires scrubbing. If you’re home with the kids, ask them to put on their favorite music — maybe you’ll become hip to a little Carly Rae Jepsen or One Direction — and just dance around together.


Next time, Glassman said, plan ahead and make things such as low-sodium, bean-based soups, frozen vegetables, peanut butter, canned tuna and salmon, green tea and oatmeal the pantry “staples.”


It’s not too late to get on the bandwagon now, she added: “Every meal is a Monday morning.”


Health News Headlines – Yahoo! News



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RBS sees PPI bill rise by £400m


























Royal Bank of Scotland has set aside a further £400m to cover the cost of claims for mis-sold payment protection insurance (PPI).





















It takes the bank’s total charges for PPI mis-selling to £1.7bn.


The figures were disclosed as RBS reported a pre-tax loss of £1.26bn for the three months to 30 September, against a £2bn profit a year earlier.


Despite the losses, chief executive Stephen Hester said that RBS was “making progress”.


The bank, which is 80%-owned by the UK government, has also set aside another £50m to cover the cost of compensation of the recent computer systems failure that hit customers.


The bank’s bill for the computer glitch, which locked many RBS, NatWest and Ulster Bank customers out of their accounts, now totals £175m.


On Wednesday, Lloyds Banking Group revealed a fresh £1bn provision for PPI claims. Along with the RBS provision, the bill for the big UK banks of the PPI scandal is now stands at £10.8bn. According to consumers’ association Which? the total figure including other financial firms, such as credit card companies, is now £12.7bn.


RBS also warned on Friday that it could be hit with stiff penalties over any involvement in the alleged manipulation of the Libor inter-bank lending rate.


The bank is being investigated by regulators in the UK, Asia and in the US, with the fraud division of the US Department of Justice also looking into the matter.


RBS bank said it expected to enter into negotiations to settle some Libor investigations in the “near term”, and that although the size of any fine was uncertain it could be big enough to have a “material” impact.


The mis-selling and other charges overshadowed underlying progress at the bank. RBS’s operating profits for the third quarter were £1bn, up from a £650m profit in the second quarter. Bad-debt losses fell by £159m from the second quarter to £1.2bn.


Staff costs were 5% lower than in the second quarter at £1.9bn, with headcount down by 9,900, or 7%, on a year earlier.


‘Reputational issues’


RBS re-stated that its restructuring after a near-collapse during the global financial crisis was on track would be completed in the next 18 months.


Mr Hester said: “The extraordinary challenges which RBS faced following the financial crisis are being worked through successfully.


“The five year restructuring plan is now in its later stages with important work still to do, including an emphasis on dealing with reputational issues now that the bank’s safety and soundness has advanced so well.”


He said that RBS “too often came to be seen” as putting the short-term interests of shareholders and staff ahead of customers, and promised to reverse the balance.


Analyst Richard Hunter, head of equities at Hargreaves Lansdown, said: “There is no doubting the immensity of the task RBS has faced in executing its turnaround plan, nor indeed the progress made so far.”


Despite the furore over bank lending to small and medium sized enterprises (SMEs), RBS maintained that its record was strong.


In the third quarter gross new lending increased by 3% compared with the second quarter. Overall gross new lending for the first nine months of 2012 was £62.9bn to UK businesses, of which £28.6bn was to SME customers.


However, RBS said there was a 25% fall in SME loan applications in the third quarter, compared with the same three months in 2011. This was due, the bank said, to uncertainty over UK economic growth and the effect of the Olympics.


RBS shares, which rose sharply on Thursday, were 1% lower in morning trading.


BBC News – Business



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Mexico’s Day of Dead brings memories of missing

























MEXICO CITY (AP) — Maria Elena Salazar refuses to set out plates of her missing son’s favorite foods or orange flowers as offerings for the deceased on Mexico‘s Day of the Dead, even though she hasn’t seen him in three-and-a-half years.


The 50-year-old former teacher is convinced that Hugo Gonzalez Salazar, a university graduate in marketing who worked for a telephone company, is still alive and being forced to work for a drug cartel because of his skills.





















“The government, the authorities, they know it, that the gangs took them away to use as forced labor,” said Salazar of her then 24-year-old son, who disappeared in the northern city of Torreon in July 2009.


The Day of the Dead — when Mexicans traditionally visit the graves of dead relatives and leave offerings of flowers, food and candy skulls — is a difficult time for the families of the thousands of Mexicans who have disappeared amid a wave of drug-fueled violence.


With what activists call a mix of denial, hope and desperation, they refuse to dedicate altars on the Nov. 1-2 holiday to people often missing for years. They won’t accept any but the most certain proof of death, and sometimes reject even that.


Numbers vary on just how many people have disappeared in recent years. Mexico’s National Human Rights Commission says 24,000 people have been reported missing between 2000 and mid-2012, and that nearly 16,000 bodies remain unidentified.


But one thing is clear: just as there are households without Day of the Dead altars, there are thousands of graves of the unidentified dead scattered across the country, with no one to remember them.


An investigation conducted by the newspaper Milenio this week, involving hundreds of information requests to state and municipal governments, indicates that 24,102 unidentified bodies were buried in paupers’ or common graves in Mexican cemeteries since 2006. The number is almost certainly incomplete, since some local governments refused to provide figures, Milenio reported.


And while the number of unidentified dead probably includes some indigents, Central American migrants or dead unrelated to the drug war, it is clear that cities worst hit by the drug conflict also usually showed a corresponding bulge in the number of unidentified cadavers. For example, Mexico City, which has been relatively unscathed by drug violence, listed about one-third as many unidentified burials as the city of Veracruz, despite the fact that Mexico City’s population is about 15 times larger.


Consuelo Morales , who works with dozens of families of disappeared in the northern city of Monterrey, said that “holidays like this, that are family affairs and are very close to our culture, stir a lot of things up” for the families. But many refuse to accept the deaths of their loved ones, sometimes even after DNA testing confirms a match with a cadaver.


“They’ll say to you, ‘I’m not going to put up an altar, because they’re not dead,” Martinez noted. “Their thinking is that ‘until they prove to me that my child is dead, he is alive.”


Martinez says one family she works with at the Citizens in Support of Human Rights center had refused to accept their son was dead, even after three rounds of DNA testing and the exhumation of the remains.


“It was their son, he was very young, and he had been burned alive,” Martinez said by way of explanation.


The refusal to accept what appears inevitable may be a matter of desperation. Martinez said some families in Monterrey also believe their missing relatives are being held as virtual slaves for the cartels, even though federal prosecutors say they have never uncovered any kind of drug cartel forced-labor camp, in the six years since Mexico launched an offensive against the cartels.


But many people like Salazar believe it must be true. “Organized crime is a business, but it can’t advertise for employees openly, so it has to take them by force,” Salazar said.


While she refuses to erect an altar-like offering for her son, she does perform other rituals that mirror the Day of the Dead customs, like the one that involves scattering a trail of flower petals to the doorsteps of houses to guide spirits of the departed back home once a year.


Salazar and her family still live in the same home in Torreon, though they’d like to move, in the hopes that Hugo will return there. They pray three times a day for God to guide him home.


“We live in the same place, and we try to do the same things we used to,” said Salazar, “because he is going to come back to his place, his home, and we have to be waiting for him.”


Mistrust of officials has risen to such a point that some families may never get an answer they’ll accept.


The problem is that, with forensics procedures often sadly lacking in Mexican police forces, the dead my never be connected with the living, which is the whole point of the Mexican traditions.


“As long as the authorities don’t prove the opposite, for us they’re still alive,” Salazar said. “Let them prove it, but let us have some certainty, not just the authorities saying ‘here he is.’ We don’t the government to just give us bodies that aren’t theirs, and that has happened.”


Latin America News Headlines – Yahoo! News



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RIM says its new BlackBerry phone in testing

























TORONTO (AP) — BlackBerry-maker Research In Motion said Wednesday that its much-delayed new smartphones are now being tested by 50 wireless carriers around the world.


The Canadian company called it a key step as it prepares to launch the new BlackBerry 10 software and phones in the first quarter of next year.





















The phones are seen as critical to RIM’s survival. The release will come as the company struggles in North America to hold onto customers who are abandoning BlackBerrys for flashier iPhones and Android phones.


“I’m very pleased to confirm that we have passed a critical milestone in the development of our brand new mobile computing platform,” RIM CEO Thorsten Heins said in a statement. “This process will continue in the coming months as more carriers around the world formally evaluate the devices and our brand new software.”


RIM’s current software is still focused on email and messaging, and is less user-friendly and agile than iPhone or Android. Its attempt at touch screens and a tablet were a flop, and RIM lacks the apps that power other smartphones. RIM’s hopes hang on BlackBerry 10. It’s thoroughly redesigned for the touchscreen, Internet browsing and apps experience that customers now expect. A full touchscreen device will be released first followed shortly after by a physical keyboard version.


Heins, who took over as CEO in January after the company lost tens of billions in market value, had vowed to do everything he could to release BlackBerry 10 this year but said in June that the timetable wasn’t realistic. Heins says he can turn things around with BlackBerry 10.


“I have spent the last several weeks on the road visiting with carrier partners around the world to show them the BlackBerry 10 platform and to share with them our plans for launch. Their response has been tremendous,” Heins said. “The hard work will not stop here as we build toward launch.”


The new BlackBerrys will be released after the holiday shopping season and well after Apple’s launch of the iPhone 5, Apple’s biggest product introduction yet.


RIM’s platform transition is also happening under a new management team and as RIM lays off 5,000 employees as part of a bid to save $ 1 billion.


RIM was once Canada’s most valuable company with a market value of more than $ 80 billion in 2008, but the stock has plummeted since, from over $ 140 share to around $ 7. Its decline evokes memories of Nortel, another former Canadian tech giant, which declared bankruptcy in 2009.


Shares of RIM closed up 4.7 percent, or 36 cents, at $ 7.93.


Wireless News Headlines – Yahoo! News



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Insight: Crunching the numbers to boost odds against cancer

























FRANKFURT (Reuters) – Software engineers are moving to the fore in the war on cancer, designing programmes that sift genetic sequencing data at lightning speed and minimal cost to identify patterns in tumors that could lead to the next medical breakthrough.


Their analysis aims to pinpoint the mutations in our genetic code that drive cancers as diverse as breast, ovarian and bowel. The more precise their work is, the better the chance of developing an effective new drug.





















Ever since James Watson and Francis Crick discovered the structure of DNA in 1953, scientists have been puzzling over how genes make us who we are. The confluence of computing and medicine is accelerating the pace of genetic research.


But making sense of the swathes of data has become a logjam.


That, in turn has created an opportunity for computer geeks and tech firms such as Microsoft, SAP and Amazon.


Oncology is the largest area of therapy in the global drugs market with market researcher IMS predicting it will increase to $ 83-$ 88 billion by 2016 from $ 62 billion in 2011. Computational genomics – using computers to decipher a person’s genetic instructions and the mutations in cancerous cells – is emerging as the driver of this growth.


Life Technologies Corp and Illumina Inc are among firms developing equipment that can extract a person’s entire genetic code – their genome – from a cell sample.


The newest machines are about the size of an office printer and can sequence a genome in a day, compared with six to eight weeks a few years ago. They can read the 3.2 billion chemical “bases” that make up the human genetic code for $ 1,000, compared with $ 100,000 dollars in 2008.


Growing numbers of software engineers are needed to help make sense of all this data.


“Many labs can now generate the data but fewer people or labs have the expertise and infrastructure to analyze it – this is becoming the bottleneck,” said Gad Getz, who heads the Cancer Genome Analysis group at the Broad Institute in Boston, jointly run by MIT and Harvard.


Getz is one of a new generation of computational biologists who develop algorithms to parse data from tens of thousands of cell samples, shared with research institutes around the globe.


He and his team of 30 are trying to establish recurring patterns in the mutations and how they are linked to tumor growth. They are using some 1,200 processing units, each with 4-8 gigabytes of random access memory – about the computing power that comes with most desktop PCs.


HARVESTING KNOWLEDGE


Eli Lilly CEO John Lechleiter sees potential for progress.


“We are starting to harvest the knowledge that we gained through the sequencing of the human genome, our understanding of human genetics, disease pathways. We’ve got new tools that we can use in the laboratory to help us get to an answer much, much faster,” said Lechleiter, whose firm is co-owner of the rights to bowel cancer drug Erbitux.


Approved drugs that take genetic information into account include Amgen’s Vectibix and AstraZeneca’s Iressa. But both these drugs derive from a single mutation. Sequencing has laid bare many more mutant genes – often hundreds in any given tumor – and highlighted the need for a subtler approach to cancer treatment.


Roche, the world’s largest maker of cancer medicines, has spent several million euros on information technology for a pilot scheme examining how cancer cells in petri dishes react to new drugs. The scheme involves crunching hundreds of terabytes of gene sequences.


“It’s the first large-scale in-house sequencing project for Roche and we expect more to follow in the near future,” said Bryn Roberts, Roche’s head of informatics in drug research and early development.


Roberts said the project, which uses processing power equivalent to hundreds of high-end desktop PCs, was self contained but there were plans to draw in external data. This would require advances in cloud computing – using software and computing power from remote data centers – but Roberts said the technology would soon be available.


“The scale of the problem means the solution will be on an international collaborative scale,” he said.


OPPORTUNITIES IN CLOUDS


The trend of using cloud computing networks to allow commercial and public researchers to share cancer data is promising for the likes of IBM and Google which according to GBI Research are already established providers of cloud computing to drug makers’ research efforts.


Amazon, with its cloud computing unit AWS, said it is benefiting as life science researchers rethink how data is stored, analyzed and shared. “We are happy with the growth we are seeing,” a spokesman said, declining to provide figures.


Microsoft said it was dedicating “significant resources” to the expansion of cloud computing in the health and life sciences markets.


“Pharma R&D will be working with other technology companies, like Microsoft, in developing new algorithms, methodologies and indeed even therapies themselves,” said Les Jordan, chief technology strategist at Microsoft’s Life Sciences unit.


The world’s largest business software company SAP has teamed up with German genetic testing specialist Qiagen. They are modifying SAP database software so that certain cancer diagnostic tests, which now keep a network of super computers busy for days, can be run on a desktop PC within hours.


Genetic analysis has revealed that types of cancer, now treated as one because they are in the same organ and look the same under the microscope, are driven by different genetics.


Hans Lehrach at the Max Planck Institute for Molecular Genetics in Berlin says every single tumor should be seen as an “orphan disease”, using a term for rare illnesses that typically prompt drug regulators to make drug approval easier.


He has designed a software he describes as a virtual patient. It suggests a drug or a mix of drugs based on each tumor’s genetic fingerprint. A single case can take several days to be processed.


Lehrach, a geneticist who says he has written software code throughout his scientific career, likens his approach to that of a meteorologist who regards every day’s set of readings as unique.


Taking the analogy further, he says the convention of stratifying cancer patients is equivalent to a weather forecast based on simple rules such as ‘red sky in the morning, sailor take warning’.


At a unit of Berlin’s Charite university hospital, 20 patients left with no other treatment options for their aggressive type of skin cancer are being diagnosed based on Lehrach’s computer model.


The trial is exploratory and there are no results yet on the overall treatment success, but the project, like many others, is driven by the hope that cancer can be wrestled down by sheer computing power.


(Additional reporting by Stephanie Nebehay; editing by Janet McBride)


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“The Details” Review: airless all-star comedy is devilishly dull

























LOS ANGELES (TheWrap.com) – The devil is in “The Details,” but only in that this smug and airless comedy feels like 91 minutes in hell. The first few minutes promise a Rube Goldberg whirligig of bad behavior, unhappy coincidences and plain old rotten luck, but all writer-director Jacob Aaron Estes (“Mean Creek”) can deliver is a group of jerks acting like jerks.


If there were any recognizable human beings on screen, this might have delivered the sort of squirmy, uncomfortable laughs that have sustained “Curb Your Enthusiasm” through multiple seasons, but the perpetrators and victims here are all such smug, dull caricatures that none of the intended satirical barbs have anywhere to land.





















Tobey Maguire stars as Jeff, a doctor who’s seemingly got the perfect house and perfect nuclear family with his wife Nealy (Elizabeth Banks) and their young son. Unfortunately, their newly-sodded backyard attracts the attention of (metaphor alert!) raccoons. Things get worse when the couple tries expanding the house to accommodate a new child, since the noise, dust and code violations all stoke the mania of their crazy-cat-lady neighbor Lila (Laura Linney).


Over the course of the film, Jeff commits horrible acts (including cheating on his wife with two different women and accidentally poisoning one of Lila’s cats) and generous ones (donating a kidney to a friend in need), and Estes delights in showing the universe punishing and rewarding Jeff purely at random, with no connection to either his sins or his good deeds.


Estes fails, however, to write any real characters, so we have a cast of talented performers trying to breathe life into people with all the depth of chess pieces. Besides Maguire (whose tendency to recede into himself is in full effect here), Banks and Linney, there’s also Kerry Washington, Dennis Haysbert and Ray Liotta trying valiantly to be more than pegs in this plot (which is less elaborate than we’re led to believe) but ultimately they are given nothing to play, nothing to do, no one to inhabit.


Ultimately, “The Details” feels frenetic when it wants to be fast-paced, and facile when it aims for some grand statement about the randomness of existence and the bitter irony of the good falling short while the evil flourish. Rarely funny, never deep and consistently exasperating, it’ll have you cheering for the raccoons.


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Shell CFO says weak Europe economy “all around us”

























LONDON (Reuters) – Europe‘s top oil company Royal Dutch Shell is seeing signs of a weak European economy “all around us,” the company’s finance director Simon Henry said during a third-quarter results conference call on Thursday.


He was making the comment in the context of strong refining margins in the quarter, which he said were more the result of supply disruptions than any strength in actual demand.





















(Reporting by Andrew Callus; Editing by David Goodman)


Economy News Headlines – Yahoo! News



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